Blar i forfatter "Songstad, Nils Thomas"

Viser treff 1-14 av 14

    • Cardiovascular adaptation in pregnancy - Effects of angiotensin II, transverse aorta constriction and high-intensity interval training on pregnant rats 

      Songstad, Nils Thomas (Doctoral thesis; Doktorgradsavhandling, 2014-09-18)
      Objectives: To investigate how cardiac function, remodeling and gene expression are affected in pregnancy in response to cardiovascular stress, to detect possible adverse effects on the fetus, and to evaluate if coronary endothelial function is influenced by pregnancy and increased cardiac afterload. Methods: Pregnant and non-pregnant rats were subjected to chronic AngII-infusion, transverse aortic ...

    • Coronary flow reserve in pregnant rats with increased left ventricular afterload 

      Songstad, Nils Thomas; Serrano, Maria; Sitras, Vasilis; Johansen, David; Ytrehus, Kirsti; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-09)
      Background Coronary flow reserve (CFR) is used as a measure of coronary endothelial function. We investigated the effect of increased afterload on CFR of pregnant and non-pregnant rats. Methods Afterload increase in Wister rats (both pregnant and non-pregnant) was achieved by the infusion of angiotensin II (Ang II) for ~10 days or by subjecting them to transverse aortic constriction (TAC) ...

    • Det enkle er ikke alltid det beste 

      Songstad, Nils Thomas (Chronicle; Kronikk, 2012)
      På slutten av 1950-tallet ble et nytt medikament introdusert på verdensmarkedet. Thalidomid ble raskt erklært som en mirakelmedisin. Stoffet virket beroligende, smertestillende og søvndyssende, og det skulle knapt ha bivirkninger. Den gode effekten på morgenkvalme gjorde at thalidomid ble særlig populært blant gravide. Konsekvensen ble katastrofal.

    • Development and Validation of a Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants at High Risk 

      Groos, Daniel; Adde, Lars; Aubert, Sindre Aarnes; Boswell, Lynn; De Regnier, Raye-Ann; Fjørtoft, Toril Larsson; Gaebler-Spira, Deborah; Haukeland, Andreas; Loennecken, Marianne; Msall, Michael; Moinichen, Unn Inger; Pascal, Aurelie; Peyton, Colleen; Ramampiaro, Heri; Schreiber, Michael D.; Silberg, Inger Elisabeth; Songstad, Nils Thomas; Thomas, Niranjan; van den Broeck, Christine; Øberg, Gunn Kristin; Ihlen, Espen Alexander F.; Støen, Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-11)
      Importance Early identification of cerebral palsy (CP) is important for early intervention, yet expert-based assessments do not permit widespread use, and conventional machine learning alternatives lack validity. Objective To develop and assess the external validity of a novel deep learning–based method to predict CP based on videos of infants’ spontaneous movements at 9 to 18 weeks’ corrected ...

    • Effect of Transverse Aortic Constriction on Cardiac Structure, Function and Gene Expression in Pregnant Rats 

      Songstad, Nils Thomas; Johansen, David; How, Ole-Jakob; Kaaresen, Per Ivar; Ytrehus, Kirsti; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: There is an increased risk of heart failure and pulmonary edema in pregnancies complicated by hypertensive disorders. However, in a previous study we found that pregnancy protects against fibrosis and preserves angiogenesis in a rat model of angiotensin II induced cardiac hypertrophy. In this study we test the hypothesis that pregnancy protects against negative effects of increased ...

    • Effects of high intensity interval training on pregnant rats, and the placenta, heart and liver of their fetuses. 

      Songstad, Nils Thomas; Kaspersen, Knut-Helge; Hafstad, Anne Dragøy; Basnet, Purusotam; Ytrehus, Kirsti; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-13)
      Objective To investigate the effects of high intensity interval training (HIIT) on the maternal heart, fetuses and placentas of pregnant rats. <p>Methods Female Sprague-Dawley rats were randomly assigned to HIIT or sedentary control groups. The HIIT group was trained for 6 weeks with 10 bouts of high intensity uphill running on a treadmill for four minutes (at 85–90% of maximal oxygen consumption) ...

    • Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: A Norwegian 2-year prospective multicenter pilot study 

      Frid, Paula; Augdal, Thomas Angell; Larheim, Tore Arne; Halbig, Josefine Mareile; Rypdal, Veronika Gjertsen; Songstad, Nils Thomas; Rosén, Annika; Tylleskär, Karin; Berstad, Johanna Elisabeth Rykke; Flatø, Berit; Stoustrup, Peter; Rosendahl, Karen; Kirkhus, Eva Astrid; Nordal, Ellen Berit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)
      <p><i>Background - </i>Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juvenile idiopathic arthritis (JIA) in a clinical setting. <p><i>Methods ...

    • Efficacy of Intravenous, Endotracheal, or Nasal Adrenaline Administration During Resuscitation of Near-Term Asphyxiated Lambs 

      Songstad, Nils Thomas; Klingenberg, Claus; McGillick, Erin V.; Polglase, Graeme R.; Zahra, Valerie; Schmölzer, Georg M.; Davis, Peter G.; Hooper, Stuart B.; Crossley, Kelly J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-02)
      <i>Objectives</i>: Neonatal resuscitation guidelines recommend administering intravenous (IV) adrenaline if bradycardia persists despite adequate ventilation and chest compressions (CC). Rapid IV access is challenging, but little evidence exists for other routes of administration. We compared IV, endotracheal (ET), and intranasal routes for adrenaline administration during resuscitation of asphyxiated ...

    • Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study 

      Ihlen, Espen Alexander F.; Støen, Ragnhild; Boswell, Lynn; de-Regnier, Raye-Ann; Fjørtoft, Toril Larsson; Gaebler-Spira, Deborah; Labori, Cathrine; Loennecken, Marianne; Msall, Michael; Møinichen, Unn Inger; Peyton, Colleen; Schreiber, Michael; Silberg, Inger Elisabeth; Songstad, Nils Thomas; Vågen, Randi; Øberg, Gunn Kristin; Adde, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      <i>Background</i>: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the Computer-based Infant Movement Assessment (CIMA) model, for clinically feasible early CP prediction based on infant video recordings.<p><p> <i>Methods</i>: The CIMA model was ...

    • May antihistone antibodies replace antinuclear antibodies (ANA) as a predictor of uveitis in Juvenile idiopathic arthritis? 

      Songstad, Nils Thomas; Nordal, Ellen Berit; Berntson, L.; Straume, Bjørn; Rygg, M. (Conference object; Konferansebidrag, 2008-09-15)

    • The Norwegian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) 

      Flatø, Berit; Rygg, Marite; Nordal, Ellen Berit; Røisland, Mona; Ødegård, Hanne Beate; Hoftun, Gry Børmark; Songstad, Nils Thomas; Consolaro, Alessandro; Bovis, Francesca; Ruperto, Nicolino (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-07)
      The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Norwegian language. The reading comprehension of ...

    • Participation in school and physical education in juvenile idiopathic arthritis in a Nordic long-term cohort study 

      Nordal, Ellen Berit; Rypdal, Veronika Gjertsen; Arnstad, Ellen Dalen; Aalto, Kristiina; Berntson, Lillemor; Ekelund, Maria; Fasth, Anders; Glerup, Mia; Herlin, Troels; Nielsen, Susan; Peltoniemi, Suvi; Zak, Marek; Songstad, Nils Thomas; Rygg, Marite (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)
      <i>Background</i> - The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA).<p> <p><i>Methods</i> - Consecutive cases of JIA from defined geographical areas of Finland, Sweden and Norway with disease onset in 1997 to 2000 were followed for 8 years in a multi-center cohort study, aimed to be ...

    • The Predictive Accuracy of the General Movement Assessment for Cerebral Palsy: A Prospective, Observational Study of High-Risk Infants in a Clinical Follow-Up Setting 

      Støen, Ragnhild; Boswell, Lynn; De Regnier, Raye-Ann; Fjørtoft, Toril Larsson; Gaebler-Spira, Deborah; Ihlen, Espen Alexander F.; Labori, Cathrine; Loennecken, Marianne; Msall, Michael E.; Moinichen, Unn Inger; Peyton, Colleen; Russow, Annamarie; Schreiber, Michael D.; Silberg, Inger Elisabeth; Songstad, Nils Thomas; Vågen, Randi Tynes; Øberg, Gunn Kristin; Adde, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-25)
      Background: Early prediction of cerebral palsy (CP) using the General Movement Assessment (GMA) during the fidgety movements (FM) period has been recommended as standard of care in high-risk infants. The aim of this study was to determine the accuracy of GMA, alone or in combination with neonatal imaging, in predicting cerebral palsy (CP). Methods: Infants with increased risk of perinatal brain ...

    • Salivary Oral Microbiome of Children With Juvenile Idiopathic Arthritis: A Norwegian Cross-Sectional Study 

      Frid, Paula; Baraniya, Divyashri; Halbig, Josefine Mareile; Rypdal, Veronika Gjertsen; Songstad, Nils Thomas; Rosén, Annika; Berstad, Johanna Elisabeth Rykke; Flatø, Berit; Alakwaa, Fadhl; Gil, Elisabeth Grut; Cetrelli, Lena Elisabet; Chen, Tsute; Al-hebshi, Nezar Noor; Nordal, Ellen Berit; Al-Haroni, Mohammed (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-04)
      <i>Background</i>: The oral microbiota has been connected to the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. The objective of this study was to characterize the salivary oral microbiome associated with juvenile idiopathic arthritis (JIA), and correlate it with the disease activity including gingival inflammation.<p> <i>Methods</i>: Fifty-nine patients with JIA ...